World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Toll-like Receptor Tlr2 and Tlr4 Polymorphisms and Chronic Obstructive Pulmonary Disease, Volume 7

By Doherty, T. Mark

Click here to view

Book Id: WPLBN0003961709
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Toll-like Receptor Tlr2 and Tlr4 Polymorphisms and Chronic Obstructive Pulmonary Disease, Volume 7  
Author: Doherty, T. Mark
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection
Historic
Publication Date:
Publisher: Plos

Description
Description : Toll-like receptors (TLRs) participate in the defence against bacterial infections that are common in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied all tagging SNPs in TLR2 and TLR4 and their associations with the level and change over time of both FEV1 and sputum inflammatory cells in moderate-to-severe COPD. Nine TLR2 SNPs and 17 TLR4 SNPs were genotyped in 110 COPD patients. Associations of SNPs with lung function and inflammatory cells in induced sputum were analyzed cross-sectionally with linear regression and longitudinally with linear mixed-effect models. Two SNPs in TLR2 (rs1898830 and rs11938228) were associated with a lower level of FEV1 and accelerated decline of FEV1 and higher numbers of sputum inflammatory cells. None of the TLR4 SNPs was associated with FEV1 level. Eleven out of 17 SNPs were associated with FEV1 decline, including rs12377632 and rs10759931, which were additionally associated with higher numbers of sputum inflammatory cells at baseline and with increase over time. This is the first longitudinal study showing that tagging SNPs in TLR2 and TLR4 are associated with the level and decline of lung function as well as with inflammatory cell numbers in induced sputum in COPD patients, suggesting a role in the severity and progression of COPD.

 

Click To View

Additional Books


  • Plos One : a New Way of Assessing Foragi... (by )
  • Plos One : Biomarkers and Bacterial Pneu... (by )
  • Plos One : Proline ; the Distribution, F... (by )
  • Plos One : Possible Association Between ... (by )
  • Plos One : Puzzling Findings in Studying... (by )
  • Plos One : Rage Genetic Polymorphisms Ar... (by )
  • Plos One : Involvement of the G-protein-... (by )
  • Plos One : Functional Dissection of the ... (by )
  • Plos One : Folate Metabolism Gene 5,10-m... (by )
  • Plos One : Jointly They Edit ; Examining... (by )
  • Plos One : M2E-displaying Virus-like Par... (by )
  • Plos One : Breastfeeding is Associated w... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Fair are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.